Bioactive Natural Products in Drug Discovery by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9789811513947
Publisher: Springer Singapore

12.12 Antimicrobial Activity

Over the previous years, a large number of synthetic antimicrobial drugs have been developed, but they are often inadequate. Moreover, serious side effects of these drugs have lead scientists to investigate alternative therapies with a view to isolate effective and safer antimicrobial agents. Ganoderma exhibits a broad spectrum of antibacterial and antiviral activities (Gao et al. 2005).

12.12.1 Antibacterial Activity

Various extracts of the fruiting bodies of Ganoderma showed antibacterial activity against Gram-positive and Gram-negative bacteria (Gao et al. 2003; Heleno et al. 2013; Ferreira et al. 2015). The methanolic extracts prepared from the mycelia of G. lucidum and G. resinaceum inhibited the growth of Bacillus subtilis and Staphylococcus aureus (Coletto and Mondino 1991). Similarly, seven Indonesian Ganoderma species suppressed the growth of B. subtilis (Sudirman and Mujiyati 1997). Furthermore, an enhanced antibacterial activity was observed when the extracts of G. lucidum were used in combination with four different antibiotics, viz., ampicillin, cefazolin, chloramphenicol, and oxytetracycline (Yoon et al. 1994). Steroids from G. applanatum and hydroquinones (ganomycins A and B) from G. pfeifferi were found to possess a broad-spectrum antibacterial activity (Mothana et al. 2000). A polysaccharide isolated from culture of G. applanatum possesses antibacterial properties against S. aureus (Osińska-Jaroszuk et al. 2014). Ethyl acetate mycelial extracts of G. australe inhibited the growth of B. subtilis, Micrococcus luteus, S. aureus, and Salmonella typhimurium (Luangharn et al. 2017). Peptide-rich fractions from G. lucidum possessed substantial antibacterial activity against Escherichia coli and S. typhi (Mishra et al. 2017).

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.